Different clinical manifestations of lymphocytic leukemia formed the basis of the classification developed by Andrey Ivanovich Vorobyov, the first Minister of Health of the Russian Federation.
Andrei Ivanovich Vorobyov cooperate is Dr. Brilliant Marina Davydovna . She very carefully led the patients and, every day, doing a blood test for them, entered the results on the temperature sheet. All doctors in the world are taught to keep such a list - only few do it.
Brilliant and Vorobyov also found that in acute radiation sickness, the change in the number of peripheral blood leukocytes over time reflects the dose of total radiation that the patient received on the bone marrow. Observation of victims in many radiation accidents of that time allowed them to learn how to determine the dose of emergency exposure with an accuracy of several tens of rads.
Andrei Ivanovich has a lot of books and publications, including about the reasons for the increase in lymphocytes.
№2 Transient lymphocytosis
Changes in the level of lymphocytes occur in conditions of psychological and physical stress, such as exercise. It is believed that this is indirectly associated with a change in catecholamines and steroid hormones. There is a redistribution of lymphocytes in the vessels of the lymphatic system. And perhaps this is due to the activation of herpes family viruses during stress, but this is my personal observation. Physically induced lymphocytosis load usually resolves within a few hours, but can be much longer.
One scientific study was conducted in a specialized hospital of 52 adults with a primary increase in lymphocytes greater than 4.0 thousand/µl.
All patients with available follow-up data showed a decrease in the absolute number of lymphocytes to normal. In some cases, stress lymphocytosis can last much longer than 48 hours and still be a temporary phenomenon. Only 1 patient showed signs of lymphoproliferative disease.
In the study of transient lymphocytosis, a great contribution was made by the Soviet and Russian medical scientist, physiologist Garkavi, Lyubov Khaimovna.
Lyubov Khaimovna found another non-specific adaptive reaction of the body, called the reactivation reaction by the author of the discovery. The reactivation reaction, as well as stress, occurs in the body to strong stimuli and has features of damage and stress, however, by the nature of the changes, it is the opposite of the stress reaction.
If the dose or strength of stress is not reduced in a timely manner, then the reaction of increased activation easily turns into stress, and sometimes into another reaction into overactivation. It is characterized by an excessive increase in the relative number of lymphocytes. And it is already characterized by a sharp increase in both glucocorticoids and mineralocorticoids, thyroid hormones. Excessive excitation predominates in the nervous system.
The video below is in Russian, but thanks to YouTube for the subtitles!